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«European Journal of Medicine» (Европейский медицинский журнал) – международный двуязычный научный журнал.

E-ISSN 2310-3434

Периодичность – 2 раза в год.
Издается с 2013 года.

1 June 30, 2020


1. Ahmed H. Al-Humairi
Relationship Between Salivary and Serum Activity of Beta-Glucuronidase and Multiple Risk Factor for Colorectal Cancer

European Journal of Medicine, 2020, 8(1): 3-9.
DOI: 10.13187/ejm.2020.1.3CrossRef

This study is directed to clarify the role of beta-glucuronidase (GUSB) in the occurrence and development of colorectal cancer (CRC). This issue is closely related to life of intestinal microflora, since we know about the beta-glucuronidase of bacterial origin, to play an important role in carcinogenesis along with its own enzyme. The study included the results of determining the specific activity of beta-glucuronidase in the blood serum and saliva. We include to research 24 volunteers who did not have or had from one to four risk factors for CRC. Additionally, we performed the fractionation of blood serum and saliva proteins to establish the possibility of native and bacterial enzyme detection. The study showed the greatest GUSB activity in blood serum and saliva to be a finding in smokers, as well as in the presence of several (three to four) risk factors for CRC. GUSB activity is also correlated with the presence of risk factors such as age and obesity. The peaks of GUSB activity, according to the results of gel chromatography, confirm the fact that bacterial forms contributed to the formation of the overall activity of this enzyme in blood serum and saliva. The obtained results can be used to create diagnostic algorithms aimed at screening for increased risk of CRC in humans based on salivary GUSB analysis.

URL: http://ejournal5.com/journals_n/1599483972.pdf
Number of views: 453      Download in PDF

2. Firas Rashad Al-Samarai, Huda Falah Hasan, Ahmed Mahmod Al-Nedawi
Impact of Diabetes Among People Infected with COVID-19

European Journal of Medicine, 2020, 8(1): 10-16.
DOI: 10.13187/ejm.2020.1.10CrossRef

This is a brief review aimed to characterize the novel coronavirus (SARS-CoV-2) for a better understanding of the COVID-19 in people with diabetes, and its management. We searched for articles in PubMed and Google Scholar databases for articles related to this subject. The clinical spectrum of COVID-19 is heterogeneous. Older age, diabetes, and other comorbidities are reported as significant predictors of morbidity and mortality. Chronic inflammation, increased coagulation activity, immune response impairment, and potential direct pancreatic damage by SARS-CoV-2 might be among the underlying mechanisms of the association between diabetes and COVID-19. Human pathogenic coronaviruses (severe acute respiratory syndrome coronavirus (SARS-CoV and SARSCoV-2) were bind to their target cells through angiotensin-converting enzyme 2 (ACE2), which is expressed by epithelial cells of the lung, intestine, kidney, and blood vessels. The expression of ACE2 is substantially increased in patients with type 1 or type 2 diabetes, who are treated with ACE inhibitors and angiotensin II type-I receptor blockers (ARBs). These data suggest that ACE2 expression is increased in diabetes with ACE inhibitors and ARBs increases ACE2 expression. Consequently, the increased expression of ACE2 would facilitate infection with COVID-19. We therefore hypothesize that diabetes treatment with ACE2-stimulating drugs increases the risk of developing severe and fatal COVID-19. Caution should be taken to potential hypoglycemic events with the use of chloroquine in diabetic patients. In conclusion: It is difficult to extract specific conclusions based on currently limited evidence. Therefore, further researches are needed to identify the real relationship between diabetic patients and COVID-19.

URL: http://ejournal5.com/journals_n/1599484028.pdf
Number of views: 479      Download in PDF

3. Nozim N. Khoshimov, Guli M. Raimova, Kabul E. Nasirov, Тuraev S. Abbaskhan
The Effect of Sulphated Cellulose on Haemostasis

European Journal of Medicine, 2020, 8(1): 17-26.
DOI: 10.13187/ejm.2020.1.17CrossRef

Background: Experimental studies and analyses of new compounds with different mechanisms of action on systemic haemostasis are relevant for the identification and development of potential pharmacological preparations. Objective: The modified sulphated polysaccharides with anticoagulant and antithrombin activity were studied for haemostasis. Methods: Platelet-rich plasma was obtained by centrifugation at 200 g for 10 minutes. The remaining citrate blood was further centrifuged at 1500 g for 10 min to obtain platelet-poor plasma. The antithrombin activity of the compounds was evaluated in vitro by their effect on the recalcification time, thrombin and prothrombin time of rabbit and human blood plasma stabilized with a 3.8 % sodium citrate solution in the ratio 9:1. Results: The results showed that the anticoagulant activity of the studied sulphates increased with an increasing degree of sulphation. Sulphated polysaccharides showed strong anticoagulant activity in vitro. The experimental results showed a significant increase in the coagulation time of blood plasma in tests for prothrombin and thrombin time. Conclusion: These properties of these components are of particular interest, and further detailed studies of the physicochemical characteristics and mechanisms of action of these molecules should be performed, which will eventually allow them to be used as heparin-like drugs.

URL: http://ejournal5.com/journals_n/1599484092.pdf
Number of views: 461      Download in PDF

4. Iryna Popova
Spatio-Temporal Morphological Changes of Structures in Infrahyoid Triangles in Human Fetuses During Fetal Period of Human Ontogenesis

European Journal of Medicine, 2020, 8(1): 27-31.
DOI: 10.13187/ejm.2020.1.27CrossRef

Infrahyoid triangles in anterior region of neck contain crucial structures for human body like trachea, thyroid gland, nerve plexuses and magistral blood vessels. Infrahyoid muscle flaps are often used for reconstructive surgeries that is why the topography of their innervation is important for successful dissection and minimization of postsurgical complications. That is why the aim of our study was to examine topographical peculiarities of structures in infrahyoid triangles in human fetuses during late intrauterine prenatal development (PND) that would provide clinical practitioners like pediatric and oncologic surgeons with additional anatomic data. We have examined 18 specimens of human fetuses (4-9th month of PND, 82,0-311,0 mm of parieto-coccigeal length (PCL)). All material was obtained and studied at Chernivtsy Regional Pathologists Office (Ukraine) in accordance with bilateral collaboration with the Department of Histology, Cytology and Embryology of BSMU. To reach the aim of the research we have used classic morphological methods (anthropometry, morphometry, layered dissection) as well as injection of the blood vessels (in 6 specimens by the means of dies) and three-dimensional reconstructioning. The study was performed in accordance with the provisions of the Declaration of Helsinki on ethical issues of studies conducted with humans (1964-2008). We have seen that in fetal period of human PND (80,0-310,0 mm of PCL) ansa cervicalis, that provides innervation for infrahyoid structures, is formed by anastomosis of the superior and inferior roots (C2 and C3) that are merging with internal carotid artery and internal jugular vein. The infrahyoid muscles receive nourishment predominantly from the superior thyroid artery, that is a branch of external carotid artery (91 %) or rarely bifurcation (3 %) and either as a branch of common carotid artery (6 %). Specific feature of infrahyoid triangles during fetal period of PND is the fact that it highly relies on bony boundaries such as mandible, sternum and clavicle that haven’t reached their mature morphology at 3rd month of PND. Investigations of topographical peculiarities of structures in infrahyoid triangles in fetal period of PND are important for successful reconstruction surgeries in postnatal and adult age.

URL: http://ejournal5.com/journals_n/1599484140.pdf
Number of views: 437      Download in PDF

5. Ali Soltaninejad, Mahin Eslamishahrbabaki, Maryam Amizadeh
Feeling Elated: A Grounded Theory Study of Rhinoplasty

European Journal of Medicine, 2020, 8(1): 32-40.
DOI: 10.13187/ejm.2020.1.32CrossRef

Background Rhinoplasty is the most common cosmetic surgery in Iran while more than half of that is not necessary. Because of lacking the qualitative studies in this field, the authors prompted to conduct this research. The aim of this study was to explore the experience of people who undergo Rhinoplasty in order to prevent unnecessary operation. Methods Sixteen participants were recruited based on the theoretical sampling from the people who referred to ENT or aesthetic clinic and by the people who knew these individuals who underwent Rhinoplasty more than one year ago. Grounded Theory was applied to analyze the data. Results All participants experienced a kind of elation so that the “feeling elated” constituted the core concept of the analysis. This feeling was reported to be experienced by all individuals through two main ways including “removing perceived defect” and “having expected beauty”. Furthermore, the main process of Rhinoplasty took place in three stages including preoccupation, inquiry, and operation. Conclusions The present study had some recommendations to the professionals so that some individuals who prefer the Rhinoplasty should be referred to the psychologist based on some criteria which are mentioned in this study. According to our findings, usually, people from the HEB group need to psychological consultations rather than surgery.

URL: http://ejournal5.com/journals_n/1599484199.pdf
Number of views: 443      Download in PDF

full number
URL: http://ejournal5.com/journals_n/1599484208.pdf
Number of views: 417      Download in PDF

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